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EPA TRI Chemical

Phenytoin

CAS Number: 57-41-0

Total releases
4.5K lbs
Number of facilities
1
Carcinogen
Yes
PBT substance
No
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Carcinogen

According to the EPA Toxics Release Inventory, Phenytoin (CAS 57-41-0) is disclosed by 1 Form R facility totaling 4.5K lbs of reported releases. The TRI extract marks this chemical with a carcinogen classification flag. TRI pounds are self-reported disclosure totals, not a measured public-health risk score.

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Phenytoin (CAS 57-41-0) is a chemical tracked by the EPA Toxics Release Inventory (TRI) program under Section 313 of the Emergency Planning and Community Right-to-Know Act. The TRI requires industrial facilities above specified threshold quantities to disclose annual manufacturing, processing, and otherwise-used volumes, along with quantities released to air, water, land, and off-site transfers.

The carcinogen flag above reflects an assessment from EPA, the International Agency for Research on Cancer, or the National Toxicology Program, not a TRI-specific determination. The largest individual disclosure in the current dataset comes from PHARMACIA & UPJOHN CO LLC A SUBSIDIARY OF PFIZER INC in MI at 4.5K lbs.

TRI volumes are self-reported estimates, not measured stack emissions, and each pound counts equally regardless of chemical toxicity, so total pounds should not be equated with total risk. Inclusion of a chemical or facility in the TRI does not itself establish a health hazard; it documents the public right-to-know record. Consult EPA's IRIS (Integrated Risk Information System) and the Agency for Toxic Substances and Disease Registry for health-effect summaries.

AIR pathway mix

Phenytoin: how the 4.5K lbs splits

4.5K lbs across all reported pathways

  • Air Releases4.5K lbs100.0%

Phenytoin's 4.5K lbs Form-R total is AIR, with air releases making up 100.0% of the bar. Off-site transfers stay separate from air, water, and land releases.

Trend & Where It's Reported

Reported Release Trend

Between 2019 and 2023, cumulative annual Phenytoin releases across all reporting facilities decreased by 29% (1.4K lbs → 1.0K lbs). Year-to-year swings reflect facility openings/closures and reporting changes as much as underlying activity.

Geographic Concentration

Reporting for Phenytoin is highly concentrated: Michigan accounts for 100.0% of the reported total (1 facility).

  • Michigan 4.5K lbs
Industry Sources

Reporting for Phenytoin is highly concentrated by industry: Chemicals facilities account for 100.0% of the reported total (1 facility).

  • Chemicals 4.5K lbs

Which facilities release the most of this chemical?

Facilities with the largest reported releases of Phenytoin. Up to 50 shown.

# Facility Release (lbs)
1 Pharmacia & Upjohn Co LLC a Subsidiary of Pfizer Inc
4.5K lbs

Frequently Asked Questions

What is Phenytoin in the EPA TRI? ▼
Phenytoin (CAS Number: 57-41-0) is a chemical tracked by the EPA Toxic Release Inventory (TRI) program. The TRI extract marks it with a carcinogen classification flag based on EPA/IARC/NTP listings. 1 facilities in the United States report releasing this chemical to the EPA.
How much Phenytoin is disclosed in U.S. TRI filings? ▼
U.S. facilities have reported a total of 4.5K lbs of Phenytoin releases to the EPA Toxic Release Inventory across 1 facilities. Release quantities are self-reported estimates covering air, water, land, and off-site transfers. They are disclosure totals, not toxicity-weighted harm scores.
How does EPA TRI classify Phenytoin? ▼
Phenytoin carries a carcinogen classification flag in the TRI database (drawn from EPA, IARC, or NTP listings). TRI classification flags document inventory listing status; they are not a site-specific exposure or health diagnosis. For health-effect summaries see EPA IRIS and ATSDR toxicological profiles.
Which facilities disclose the most Phenytoin? ▼
Pharmacia & Upjohn Co LLC a Subsidiary of Pfizer Inc in MI reports the largest disclosed release of Phenytoin in this dataset, at 4.5K lbs. Most reporting facilities for this chemical fall under chemicals. Release data is self-reported annually to the EPA under the TRI program. View the full list of 1 facilities on this page.
What is the CAS number for Phenytoin? ▼
The CAS (Chemical Abstracts Service) Registry Number for Phenytoin is 57-41-0. CAS numbers are unique numerical identifiers assigned to every chemical substance described in the open scientific literature. This identifier is used to search scientific databases and regulatory filings.

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Health Information

Carcinogen Classification: This chemical is classified as a known or suspected carcinogen by the EPA under the Toxic Release Inventory program. This classification is based on evaluations by agencies including the International Agency for Research on Cancer (IARC), the National Toxicology Program (NTP), and the EPA itself.

Data comes from the EPA Toxic Release Inventory (TRI) program. Release quantities are self-reported by facilities and may represent estimates. The total shown aggregates reports across all facilities and reporting years.

PlainEnviro presents this data without advocacy framing. The presence of a chemical in the TRI database does not by itself indicate a health risk at current exposure levels. For health-related questions about specific chemical exposures, consult your local health agency or a toxicologist.

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Data sourced from the U.S. Environmental Protection Agency (EPA). See our methodology for details. Retrieved and formatted by PlainEnviro

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from the EPA Toxic Release Inventory (TRI). Consult a qualified professional before making decisions based on this data.

Read our methodology - how this data is sourced, computed, and verified.