| 1 | Smithfield Packaged Meats Corp - Sioux Falls | Sioux Falls | Food | 21.3M lbs | 4 |
| 2 | Wharf Resources | Lead | Metal Mining | 8.0M lbs | 11 |
| 3 | Novita Aurora LLC | Aurora | Food | 2.5M lbs | 1 |
| 4 | Otter Tail Power Co Big Stone Plant | Big Stone City | Electric Utilities | 2.2M lbs | 11 |
| 5 | South Dakota Soybean Processors | Volga | Food | 2.0M lbs | 1 |
| 6 | Ag Processing Inc | Aberdeen | Food | 1.3M lbs | 1 |
| 7 | New Angus LLC | Aberdeen | Food | 836.6K lbs | 3 |
| 8 | Workhorse Cabs LLC DBA Crenlo Engineered Cabs | Watertown | Machinery | 775.7K lbs | 5 |
| 9 | Masterbrand Cabinets LLC | Sioux Falls | Furniture | 421.0K lbs | 5 |
| 10 | Design Tanks LLC | Sioux Falls | Plastics and Rubber | 247.4K lbs | 1 |
| 11 | Showplace Wood Products | Harrisburg | Furniture | 227.8K lbs | 4 |
| 12 | Solventum Brookings | Brookings | Miscellaneous Manufacturing | 224.5K lbs | 5 |
| 13 | Hydro Extrusion USA LLC | Yankton | Primary Metals | 223.2K lbs | 12 |
| 14 | Poet Biorefining - Hudson | Hudson | Chemicals | 203.9K lbs | 9 |
| 15 | Dakota Ethanol LLC | Wentworth | Chemicals | 194.4K lbs | 11 |
| 16 | Pete Lien & Sons Inc | Rapid City | Nonmetallic Mineral Product | 193.6K lbs | 7 |
| 17 | Marmen Energy Co | Brandon | Fabricated Metals | 192.0K lbs | 3 |
| 18 | Glacial Lakes Energy LLC | Watertown | Chemicals | 162.9K lbs | 8 |
| 19 | Aberdeen Energy LLC | Mina | Chemicals | 161.1K lbs | 8 |
| 20 | Woodland Cabinetry Inc | Sisseton | Furniture | 143.6K lbs | 3 |
| 21 | Gcc Dacotah | Rapid City | Nonmetallic Mineral Product | 130.1K lbs | 9 |
| 22 | Ring-Neck Energy & Feed LLC | Onida | Chemicals | 125.7K lbs | 9 |
| 23 | Valero Renewable Fuels Llc* | Aurora | Chemicals | 113.6K lbs | 9 |
| 24 | Nugen Energy LLC | Marion | Chemicals | 105.2K lbs | 9 |
| 25 | Poet Holding Co LLC | Groton | Beverages | 104.0K lbs | 10 |
| 26 | Valley Queen Cheese Factory Inc. | Milbank | Food | 101.4K lbs | 5 |
| 27 | Red River Energy LLC | Rosholt | Chemicals | 99.6K lbs | 8 |
| 28 | Poet Biorefining - Chancellor | Chancellor | Chemicals | 95.6K lbs | 12 |
| 29 | Huron Energy | Huron | Chemicals | 87.1K lbs | 4 |
| 30 | Poet Biorefining-Big Stone LLC | Big Stone City | Chemicals | 86.8K lbs | 9 |
| 31 | Dakota Fiberglass Inc. | Webster | Plastics and Rubber | 69.6K lbs | 1 |
| 32 | Redfield Energy LLC | Redfield | Chemicals | 69.5K lbs | 9 |
| 33 | Hub City Energy LLC | Aberdeen | Chemicals | 59.9K lbs | 5 |
| 34 | Fiberglass Specialties Inc | Watertown | Plastics and Rubber | 52.0K lbs | 1 |
| 35 | Prairie Ethanol LLC (dba Poet Biorefining) Mitchell | Mitchell | Chemicals | 41.9K lbs | 9 |
| 36 | Poet Research Center Inc. | Scotland | Chemicals | 17.0K lbs | 3 |
| 37 | Dairi Concepts | Pollock | Food | 14.7K lbs | 4 |
| 38 | Henkel of America Inc. | Brandon | Chemicals | 12.3K lbs | 3 |
| 39 | Midwest Manufacturing Inc DBA Dakota Panel | Rapid City | Wood Products | 11.8K lbs | 2 |
| 40 | Omega Liner Co Inc. | Canton | Plastics and Rubber | 5.0K lbs | 1 |
| 41 | Load King Trailers | Elk Point | Transportation Equipment | 4.8K lbs | 6 |
| 42 | Chs Corson Feed | Corson | Food | 4.6K lbs | 5 |
| 43 | Global Polymer Industries Inc | Madison | Plastics and Rubber | 4.0K lbs | 1 |
| 44 | Astec - Yankton | Yankton | Machinery | 3.2K lbs | 1 |
| 45 | Royal Canin USA Inc. | North Sioux City | Food | 2.6K lbs | 1 |
| 46 | Associated Milk Producers Inc. | Freeman | Food | 2.5K lbs | 2 |
| 47 | Dakota Bodies LLC | Watertown | Transportation Equipment | 2.1K lbs | 6 |
| 48 | Manitou Equipment America LLC - Yankton | Yankton | Machinery | 2.0K lbs | 2 |
| 49 | Knife River-Madison Street | Sioux Falls | Nonmetallic Mineral Product | 1.7K lbs | 5 |
| 50 | Manitou Equipment America Llc. - Madison | Madison | Machinery | 1.7K lbs | 2 |
| 51 | U.S. Dod Usaf, Ellsworth Afb | Ellsworth Afb | Other | 1.5K lbs | 6 |
| 52 | Cimpl's LLC | Yankton | Food | 1.3K lbs | 2 |
| 53 | Miller Electric Manufacturing Co | Watertown | Fabricated Metals | 957 lbs | 2 |
| 54 | Terex South Dakota Inc | Huron | Machinery | 945 lbs | 1 |
| 55 | Knife River-Rice Street | Sioux Falls | Nonmetallic Mineral Product | 879 lbs | 5 |
| 56 | Tech Ord | Clear Lake | Fabricated Metals | 828 lbs | 2 |
| 57 | Diamond Mowers Inc. | Sioux Falls | Machinery | 423 lbs | 4 |
| 58 | Truenorth Steel - Huron | Huron | Fabricated Metals | 304 lbs | 2 |
| 59 | Knife River-Yankton | Yankton | Nonmetallic Mineral Product | 290 lbs | 5 |
| 60 | Wilson Trailer Co | Yankton | Transportation Equipment | 189 lbs | 4 |
| 61 | Wilson Trailer Co | Lennox | Transportation Equipment | 188 lbs | 4 |
| 62 | Graco Inc Sioux Falls | Sioux Falls | Machinery | 162 lbs | 6 |
| 63 | Horton Inc | Britton | Transportation Equipment | 103 lbs | 3 |
| 64 | Trail King Industries Inc. | Mitchell | Transportation Equipment | 100 lbs | 4 |
| 65 | Hansen Manufacturing DBA Hi-Roller Conveyors | Sioux Falls | Machinery | 92 lbs | 4 |
| 66 | L&m Radiator Inc. | Yankton | Transportation Equipment | 86 lbs | 1 |
| 67 | Truenorth Steel - Rapid City | Rapid City | Fabricated Metals | 79 lbs | 2 |
| 68 | US Dod Usaf Joe Foss Field Ang Sd | Sioux Falls | Other | 60 lbs | 3 |
| 69 | Curt Manufacturing LLC | Brandon | Fabricated Metals | 51 lbs | 5 |
| 70 | Harvard Integrations | Tea | Fabricated Metals | 44 lbs | 2 |
| 71 | Hendrickson Trailer Suspension Systems | Mitchell | Transportation Equipment | 43 lbs | 2 |
| 72 | Vermeer Corp | Freeman | Machinery | 33 lbs | 1 |
| 73 | Trail-Eze | Mitchell | Transportation Equipment | 25 lbs | 1 |
| 74 | Dakota Mfg Co Inc | Corsica | Transportation Equipment | 25 lbs | 1 |
| 75 | Hancock Concrete Products | Sioux Falls | Nonmetallic Mineral Product | 21 lbs | 2 |
| 76 | Twin City Fan Cos Brookings | Brookings | Machinery | 21 lbs | 2 |
| 77 | Safety-Kleen Systems | Sioux Falls | Hazardous Waste | 20 lbs | 1 |
| 78 | Terex South Dakota | Watertown | Machinery | 14 lbs | 2 |
| 79 | Twin City Fan Cos Aberdeen | Aberdeen | Machinery | 11 lbs | 2 |
| 80 | Twin City Fan Cos Insbrook | Brookings | Machinery | 11 lbs | 2 |
| 81 | Dakota Mfg Co Inc | Platte | Transportation Equipment | 10 lbs | 1 |
| 82 | Dakota Turkey Growers | Huron | Food | 5 lbs | 1 |
| 83 | Permian Tank & Manufacturing Inc Belle Fourche Plant | Belle Fourche | Fabricated Metals | 3 lbs | 4 |
| 84 | Tcc - Sioux Falls | Sioux Falls | Nonmetallic Mineral Product | 3 lbs | 1 |
| 85 | Vishay-Dale Electronics | Yankton | Computers and Electronic Products | 1 lbs | 4 |
| 86 | Agropur Inc. | Lake Norden | Food | 1 lbs | 2 |
| 87 | Star Circuits Inc | Brookings | Computers and Electronic Products | 1 lbs | 1 |
| 88 | Raven Industries Inc. | Sioux Falls | Computers and Electronic Products | 0 lbs | 3 |
| 89 | Forterra Concrete Products - Rapid City | Rapid City | Nonmetallic Mineral Product | 0 lbs | 1 |
| 90 | Cemcast Pipe & Precast LLC | Hartford | Nonmetallic Mineral Product | 0 lbs | 4 |
| 91 | Gates Corp | Brandon | Fabricated Metals | 0 lbs | 1 |
| 92 | Electronic Systems Inc | Sioux Falls | Computers and Electronic Products | 0 lbs | 1 |
| 93 | Alkota Cleaning Systems Inc | Alcester | Machinery | 0 lbs | 1 |
| 94 | Daktronics Inc | Brookings | Miscellaneous Manufacturing | 0 lbs | 1 |
| 95 | Gcc-Brookings | Brookings | Nonmetallic Mineral Product | 0 lbs | 3 |
| 96 | Allied Oil & Tire Co LLC | Brandon | Petroleum Bulk Terminals | 0 lbs | 2 |
| 97 | Alex C. Fergusson LLC | Brandon | Chemicals | 0 lbs | 4 |
| 98 | Rosenbauer South Dakota LLC | Lyons | Transportation Equipment | 0 lbs | 1 |
| 99 | Baldwin Filters Inc | Yankton | Transportation Equipment | 0 lbs | 3 |
| 100 | Daktronics Inc | Sioux Falls | Miscellaneous Manufacturing | 0 lbs | 1 |
| 101 | Purina Animal Nutrition LLC - Sioux Falls Sd | Sioux Falls | Food | 0 lbs | 3 |
| 102 | Hoh Water Technology Inc | Sioux Falls | Chemicals | 0 lbs | 1 |
| 103 | Hubbard Feeds Inc Watertown Sd | Watertown | Food | 0 lbs | 1 |
| 104 | Spartronics Watertown LLC | Watertown | Computers and Electronic Products | 0 lbs | 2 |
| 105 | Twin City Die Castings Co - Watertown Div | Watertown | Primary Metals | 0 lbs | 2 |
| 106 | Gcc-Watertown | Watertown | Nonmetallic Mineral Product | 0 lbs | 3 |
| 107 | Chs Farmers Alliance - Corsica Feed | Corsica | Food | 0 lbs | 4 |
| 108 | Hubbard Feeds Inc Huron | Huron | Food | 0 lbs | 3 |
| 109 | Gcc-Huron | Huron | Nonmetallic Mineral Product | 0 lbs | 2 |
| 110 | Hub City Inc | Aberdeen | Machinery | 0 lbs | 3 |
| 111 | Gcc-Aberdeen | Aberdeen | Nonmetallic Mineral Product | 0 lbs | 2 |
| 112 | Chs Gettysburg Feed | Gettysburg | Food | 0 lbs | 2 |
| 113 | Associated Milk Producers Inc. | Hoven | Food | 0 lbs | 1 |
| 114 | Forest Products Distributors Inc | Rapid City | Wood Products | 0 lbs | 3 |
| 115 | Hubbard Feeds Inc | Rapid City | Food | 0 lbs | 2 |
| 116 | Ridley Block Operations | Whitewood | Food | 0 lbs | 2 |
| 117 | Hills Products Group | Whitewood | Wood Products | 0 lbs | 3 |
| 118 | Wheeler Lumber L.L.C. | Whitewood | Wood Products | 0 lbs | 1 |
| 119 | Consumers Supply - North Sioux | North Sioux City | Food | 0 lbs | 4 |
| 120 | Knife River Corson Ready Mix Plant | Brandon | Nonmetallic Mineral Product | 0 lbs | 1 |
| 121 | Dakotaland Feeds LLC | Huron | Food | 0 lbs | 5 |
| 122 | Dakota Tube Building 1 | Watertown | Fabricated Metals | 0 lbs | 1 |
| 123 | Dakota Tube Building 3 | Watertown | Fabricated Metals | 0 lbs | 1 |
| 124 | 3M Co | Aberdeen | Textiles | 0 lbs | 1 |